fibrodysplasia ossificans progressiva

== English == === Etymology === From English fibrodysplasia, and borrowed from New Latin ossificans + Latin prōgressīvā, literally “abnormal development of fibrous tissue with ossification that is progressive”: Fibrodysplasia is derived from fibro- (prefix meaning ‘fibre; fibrous’) (from Latin fibra (“fibre; filament”), ultimately from Proto-Indo-European *bʰeyd- (“to split”)) + dysplasia (“abnormal development of cells or tissue”) (from dys- (prefix meaning ‘abnormal; disease’) + -plasia (suffix meaning ‘formation; growth’)). Ossificans is from Latin ossīs (a plural form of ossum (“bone”), ultimately from Proto-Indo-European *h₃ésth₁ (“bone”)) + -ficāns (the present active participle of -ficō (suffix forming chiefly causative or factitive verbs)). Prōgressīvā is the ablative feminine singular of prōgressīvus (“progressive”), from prōgressus (“advanced, proceeded; developed, progressed”) (the perfect active participle of prōgredior (“to advance, proceed; (figurative) to develop, progress”), from prō- (prefix denoting a forward direction) + gradior (“to step; to walk; to advance”) (ultimately from Proto-Indo-European *gʰredʰ- (“to go; to walk”))) + -īvus (suffix forming adjectives). The disease was originally termed myositis ossificans progressiva in 1868. The use of fibrodysplasia in place of myositis was suggested by K. H. Bauer and W. Bode in 1940, and adopted by the American medical geneticist Victor A. McKusick (1921–2008) in his work Heritable Disorders of Connective Tissue (1956). === Pronunciation === (Received Pronunciation) IPA(key): /ˌfaɪbɹəʊdɪsˈpleɪzɪə ɒˈsɪfɪkɑːnz pɹəˈɡɹɛsɪvə/, /-ˈpleɪʒə-/ (General American) IPA(key): /ˌfaɪbɹoʊdɪsˈpleɪʒ(i)ə ɒˈsɪfɪkænz pɹəˈɡɹɛsɪvə/, /-ˈpleɪziə-/, /-pɹoʊ-/ Hyphenation: fi‧bro‧dys‧plas‧ia os‧si‧fi‧cans pro‧gress‧i‧va === Noun === fibrodysplasia ossificans progressiva (uncountable) (medical genetics) A very rare, disabling genetic disorder of the connective tissue in which fibrous tissue (including ligaments, muscles, and tendons) ossifies (“transforms into bone”) when damaged. Synonyms: (abbreviation) FOP, Münchmeyer disease, (obsolete) myositis ossificans progressiva, stone man syndrome ==== Translations ==== === References === === Further reading === fibrodysplasia ossificans progressiva on Wikipedia.Wikipedia “fibrodysplasia ossificans progressiva, n.”, in Merriam-Webster.com Medical Dictionary, Springfield, Mass.: Merriam-Webster, reproduced from Merriam-Webster’s Medical Dictionary, new edition, Springfield, Mass.: Merriam-Webster, 2016, →ISBN.